Cambridge University Press
9780521872898 - Infertility in the Male - Fourth Edition - Edited by Larry I. Lipshultz, Stuart S. Howards and Craig S. Niederberger
Frontmatter/Prelims

Infertility in the Male: Fourth Edition


Infertility in the Male

Fourth Edition

Edited by

Larry I. Lipshultz, Stuart S. Howards and Craig S. Niederberger


CAMBRIDGE UNIVERSITY PRESS
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Cambridge University Press
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Published in the United States of America by Cambridge University Press, New York

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Information on this title: www.cambridge.org/9780521872898

First edition © L. I. Lipshultz and S. S. Howards 1983
Second and third edition © Mosby Year Book 1991, 1997
Fourth edition © Cambridge University Press 2009

This publication is in copyright. Subject to statutory exception and to the provisions of relevant collective licensing agreements, no reproduction of any part may take place without the written permission of Cambridge University Press.

First edition published by Churchill Livingstone 1983
Second and third edition published by Mosby Year Book 1991, 1997
Fourth edition published by Cambridge University Press 2009

Printed in the United Kingdom at the University Press, Cambridge

A catalogue record for this publication is available from the British Library

Library of Congress Cataloguing in Publication data

Infertility in the male / [edited by] Larry I. Lipshultz, Stuart S.
Howards, Craig S. Niederberger. – 4th ed.
p.;cm..
Includes bibliographical references and index.
ISBN 978–0-521–87289-8 (hardback)
1.Infertility, Male.I. Lipshultz, Larry I., 1942–II.Howards,
Stuart S., 1937–III.Niederberger, Craig S.
[DNLM: 1. Infertility, Male. WJ 709 I43 2009]
RC889.I563 2009
616.6′92–dc22 2009027850.

ISBN 978-0-521-87289-8 Hardback

Cambridge University Press has no responsibility for the persistence or accuracy of URLs for external or third-party internet websites referred to in this publication, and does not guarantee that any content on such web sites is or will remain, accurate or appropriate.Every effort has been made in preparing this publication to provide accurate and up-to-date information which is in accord with accepted standards and practice at the time of publication. Although case histories are drawn from actual cases, every effort has been made to disguise the identities of the individuals involved. Nevertheless, the authors, editors and publishers can make no warranties that the information contained herein is totally free from error, not least because clinical standards are constantly changing through research and regulation. The authors, editors and ublishers therefore disclaim all liability for direct or consequential damages resulting from the use of material contained in this publication. Readers are strongly advised to pay careful attention to information provided by the manufacturer of any drugs or equipment that they plan to use.


Contents

List of contributors
vii
Foreword by Alan H. DeCherney
xi
1     Anatomy and embryology of the male reproductive tract and gonadal development
Jane M. Lewis & William E. Kaplan
1
2     Male hypothalamic–pituitary–gonadal axis
Ettore Caroppo
14
3     Leydig cell development and function
Barry R. Zirkin, Vassilios Papadopoulos, & Matthew P. Hardy
29
4     The Sertoli cell: morphology, function, and regulation
Joseph P. Alukal & Dolores J. Lamb
48
5     Spermatogenesis in the adult
Joseph P. Alukal, Dolores J. Lamb, Craig S. Niederberger, & Antoine A. Makhlouf
74
6     The epididymis and accessory sex organs
Terry T. Turner
90
7     An overview of the molecular mechanisms involved in human fertilization
Mónica H. Vazquez-Levin & Clara I. Marín-Briggiler
104
8     New concepts in the genetics of male reproduction and infertility
Paul J. Turek
122
9     Erection, emission, and ejaculation: mechanisms of control
Alexander Müller & John P. Mulhall
132
10    Office evaluation of the subfertile male
Mark Sigman, Larry I. Lipshultz, & Stuart S. Howards
153
11    Evaluation of sperm function
Armand Zini & Mark Sigman
177
12    Endocrine evaluation
Rebecca Z. Sokol
199
13    Testicular biopsy in male infertility evaluation
Joseph P. Alukal, Mohit Khera, & Thomas M. Wheeler
215
14    Adverse effects of environmental chemicals and drugs on the male reproductive system
James V. Bruckner, David M. Fenig, & Larry I. Lipshultz
226
15    Genetic aspects of infertility
Robert D. Oates & Dolores J. Lamb
251
16    Immunologic infertility
Thomas J. Walsh & Paul J. Turek
277
17    The effect of genital tract infection and inflammation on male infertility
Sanjay S. Kasturi, E. Charles Osterberg, Justin Tannir, & Robert E. Brannigan
295
18    Varicocele
Harris M. Nagler & Aaron B. Grotas
331
19    Evaluation of female infertility for the non-gynecologist
R. Dale McClure & Nancy A. Klein
362
20    The use of ultrasound and radiologic imaging in the diagnosis of male infertility
Saleh Binsaleh, Myles Margolis, Keith Jarvi, & Kirk C. Lo
375
21    Microsurgical treatment of male infertility
Edmund S. Sabanegh Jr. & Anthony J. Thomas Jr.
392
22    Techniques of sperm retrieval
Edward Karpman & Daniel H. Williams IV
407
23    Management of ejaculatory duct obstruction
Aleksander Chudnovsky & Victor M. Brugh III
421
24    Nonsurgical treatment of male infertility: specific therapy
Jesse N. Mills & Randall B. Meacham
430
25    Nonsurgical treatment of male infertility: empiric therapy
Karen E. Boyle
438
26    Abnormalities of ejaculation
Nancy L. Brackett, Dana A. Ohl, Jens Sønksen, & Charles M. Lynne
454
27    Male contraception and vasectomy
Stanton C. Honig & Jay I. Sandlow
474
28    Intrauterine insemination from the urologist’s perspective
Christine Mullin, James Stelling, & Richard A. Schoor
493
29    In-vitro fertilization and micromanipulation for male infertility
Rodrigo L. Pagani, Paulo C. Serafini, & Miguel Srougi
500
30    Psychological issues of infertility and assisted reproductive technology
Linda D. Applegarth
516
31    Legal issues in fertility preservation in the male
Susan L. Crockin & Elizabeth M. Bloom
528
32    Analyzing male fertility data
Antoine A. Makhlouf & Craig S. Niederberger
541
33    Semen analysis
Susan A. Rothmann & Angela A. Reese
550
34    Strict criteria for sperm morphology
Grace M. Centola & Rajasingam S. Jeyendran
574
35    Sperm processing techniques
Grace M. Centola & Rajasingam S. Jeyendran
582
36    Sperm banking: indications and techniques
Moshe Wald & Gail S. Prins
593
37    Tests for antisperm antibodies
Suresh C. Sikka & Wayne J. G. Hellstrom
603
38    Semen white blood cell assay
Joseph A. Politch & Deborah J. Anderson
613
39    Determination of seminal oxidants (reactive oxygen species)
Ashok Agarwal & Fnu Deepinder
618
40    Measurement of DNA fragmentation in human spermatozoa
Denny Sakkas
633
41    A look towards the future: advances in andrology expected to revolutionize the diagnosis and treatment of the infertile male
Dolores J. Lamb
642
Index
654

Contributors

Ashok Agarwal PhD HCLD

Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA

Joseph P Alukal MD

Department of Urology, NYU School of Medicine, New York, NY, USA

Deborah J Anderson PhD

Department of Obstetrics & Gynecology, Boston University School of Medicine, Boston, MA, USA

Linda D Applegarth EdD

The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine & Infertility, Weill Medical College of Cornell University, New York, NY, USA

Saleh Binsaleh MD FRCSC

Division of Urology, Department of Surgery, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia

Elizabeth M Bloom JD

New England School of Law, Boston, MA, USA

Karen E Boyle MD

Shady Grove Fertility Reproductive Science Center, Rockville, MD, & Greater Baltimore Medical Center (GBMC), Baltimore, MD, USA

Nancy L Brackett PhD HCLD

The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL, USA

Robert E Brannigan MD

Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

James V Bruckner PhD

Department of Pharmaceutical & Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, GA, USA

Victor M Brugh III MD

Department of Urology, Eastern Virginia Medical School, Norfolk, VA, USA

Ettore Caroppo MD

ASL BARI, Reproductive Unit, Conversano, Bari, Italy

Grace M Centola PhD

LifeCell Dx, Inc., Buffalo, NY; New England Cryogenic Center, Newton, MA, USA

Aleksander Chudnovsky MD

Division of Urology, University of Massachusetts, Worcester, MA, USA

Susan L Crockin JD

The Crockin Law & Policy Group LLC, Newton, MA, USA

Fnu Deepinder MD

Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA

David M. Fenig

Department of Pharmaceutical & Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, GA, USA

Aaron B Grotas MD

Sol & Margaret Berger Department of Urology, Beth Israel Medical Center, New York, NY, USA

Matthew P. Hardy (deceased)

Population Council, New York, NY, USA

Wayne J. G. Hellstrom MD

Department of Urology, Tulane University Health Sciences Center, New Orleans, LA, USA

Stanton C Honig MD

Urology Center, New Haven, CT, & Division of Urology, University of Connecticut, Farmington, CT, USA

Stuart S Howards MD

Department of Urology, University of Virginia School of Medicine, Charlottesville, VA, USA

Keith Jarvi MD FRCSC

Division of Urology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada

Rajasingam S Jeyendran PhD

Andrology Laboratory Services, Inc., Chicago, IL, USA

William E Kaplan MD

Division of Pediatric Urology, Children’s Memorial Hospital, Chicago, IL, USA

Edward Karpman MD

El Camino Urology, Mountain View, CA, USA

Sanjay S Kasturi MD

Department of Urology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA

Mohit Khera MD MBA MPH

Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA

Nancy A Klein MD

Seattle Reproductive Medicine, Seattle, WA, USA

Dolores J Lamb PhD HCLD

Scott Department of Urology and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA

Jane M Lewis MD

Department of Urologic Surgery, University of Minnesota, Minneapolis, MN, USA

Larry I Lipshultz MD

Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA

Kirk C Lo MD CM FRCSC

Division of Urology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada

Charles M Lynne MD

Department of Urology, University of Miami Miller School of Medicine, Miami, FL, USA

R. Dale McClure MD FACS FRCSC

Department of Urology, Virginia Mason Medical Center, Seattle, WA, USA

Antoine A Makhlouf MD PhD

Department of Urologic Surgery, University of Minnesota, Minneapolis, MN, USA

Myles Margolis MD FRCPC

Department of Medical Imaging, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada

Clara I. Marín-Briggiler PhD

Laboratory of Molecular Studies of the Gamete Interaction Process, Instituto de Biología y Medicina Experimental, CONICET, Buenos Aires, Argentina

Randall B Meacham MD

Division of Urology, University of Colorado School of Medicine, Denver, CO, USA

Jesse N Mills MD

The Urology Center of Colorado, Denver, CO, USA

John P Mulhall MD

Urology Service, Memorial Sloan–Kettering Cancer Center, New York, NY, USA

Alexander Müller MD

Urology Service, Memorial Sloan–Kettering Cancer Center, New York, NY, USA

Christine Mullin MD

Rockville Centre, NY, USA

Harris M Nagler MD FACS

Sol and Margaret Berger Department of Urology, Beth Israel Medical Center & Albert Einstein College of Medicine, Yeshiva University, NY, USA

Craig S Niederberger MD FACS

Department of Urology, UIC College of Medicine, & Department of Bioengineering, UIC College of Engineering, University of Illinois at Chicago, Chicago, IL, USA

Robert D Oates MD

Department of Urology, Boston University School of Medicine, Boston, MA, USA

Dana A Ohl MD

Department of Urology, University of Michigan, Ann Arbor, MI, USA

E. Charles Osterberg BS

Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

Rodrigo L Pagani MD

Department of Urology, University of São Paulo School of Medicine, São Paulo, Brazil

Vassilios Papadopoulos DPharm PhD

The Research Institute of the McGill University Health Center and Department of Medicine, McGill University, Montreal, Quebec, Canada

Joseph A Politch PhD

Department of Obstetrics & Gynecology, Boston University School of Medicine, Boston, MA, USA

Gail S Prins PhD

Department of Urology, UIC College of Medicine, University of Illinois at Chicago, Chicago, IL, USA

Angela A Reese BS

Fertility Solutions Inc, Cleveland, OH, USA

Susan A Rothmann PhD HCLD

Fertility Solutions Inc, Cleveland, OH, USA

Edmund S Sabanegh Jr. MD

Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA

Denny Sakkas PhD

Department of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA

Jay I Sandlow MD

Department of Urology, Medical College of Wisconsin, Milwaukee, WI, USA

Richard A Schoor MD FACS

Private Practice Urology, Smithtown, NY, USA

Paulo C Serafini MD

Department of Gynecology, University of São Paulo School of Medicine, São Paulo, Brazil

Mark Sigman MD

Division of Urology (Department of Surgery), Brown University, Providence, RI, USA

Suresh C Sikka PhD HCLD

Andrology Clinical Laboratories, Department of Urology, Tulane University Health Sciences Center, New Orleans, LA, USA

Rebecca Z Sokol MD MPH

Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

Jens Sønksen MD DMSci PhD

Department of Urology, Herlev Hospital, Herlev, Denmark

Miguel Srougi MD

Department of Urology, University of São Paulo School of Medicine, São Paulo, Brazil

James Stelling MD

Reproductive Specialists of New York, Stony Brook, NY, USA

Justin Tannir MD

Department of Ophthalmology, Kresge Eye Institute, Detroit Medical Center, Detroit, MI, USA

Anthony J Thomas Jr. MD

Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA

Paul J Turek MD

The Turek Clinic, San Francisco, CA, USA

Terry T Turner PhD

Department of Urology, University of Virginia School of Medicine, Charlottesville, VA, USA

Mónica H. Vazquez-Levin PhD

Laboratory of Molecular Studies of the Gamete Interaction Process, Instituto de Biología y Medicina Experimental, CONICET, Buenos Aires, Argentina

Moshe Wald MD

Department of Urology, University of Iowa, Iowa City, IA, USA

Thomas J Walsh MD MS

Department of Urology, University of Washington School of Medicine, Seattle, WA, USA

Thomas M Wheeler MD

Department of Pathology, Baylor College of Medicine, Houston, TX, USA

Daniel H Williams IV MD

Department of Urology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA

Armand Zini MD

Division of Urology, McGill University, Montreal, Quebec, Canada

Barry R Zirkin PhD

Division of Reproductive Biology, Department of Biochemistry & Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA





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