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First edition © L. I. Lipshultz and S. S. Howards 1983
Second and third edition © Mosby Year Book 1991, 1997
Fourth edition © Cambridge University Press 2009
This publication is in copyright. Subject to statutory exception and to the provisions of relevant collective licensing agreements, no reproduction of any part may take place without the written permission of Cambridge University Press.
First edition published by Churchill Livingstone 1983
Second and third edition published by Mosby Year Book 1991, 1997
Fourth edition published by Cambridge University Press 2009
Printed in the United Kingdom at the University Press, Cambridge
A catalogue record for this publication is available from the British Library
Library of Congress Cataloguing in Publication data
Infertility in the male / [edited by] Larry I. Lipshultz, Stuart S. Howards, Craig S. Niederberger. – 4th ed. p.;cm.. Includes bibliographical references and index. ISBN 978–0-521–87289-8 (hardback) 1.Infertility, Male.I. Lipshultz, Larry I., 1942–II.Howards, Stuart S., 1937–III.Niederberger, Craig S. [DNLM: 1. Infertility, Male. WJ 709 I43 2009] RC889.I563 2009 616.6′92–dc22 2009027850.
ISBN 978-0-521-87289-8 Hardback
Cambridge University Press has no responsibility for the persistence or accuracy of URLs for external or third-party internet websites referred to in this publication, and does not guarantee that any content on such web sites is or will remain, accurate or appropriate.Every effort has been made in preparing this publication to provide accurate and up-to-date information which is in accord with accepted standards and practice at the time of publication. Although case histories are drawn from actual cases, every effort has been made to disguise the identities of the individuals involved. Nevertheless, the authors, editors and publishers can make no warranties that the information contained herein is totally free from error, not least because clinical standards are constantly changing through research and regulation. The authors, editors and ublishers therefore disclaim all liability for direct or consequential damages resulting from the use of material contained in this publication. Readers are strongly advised to pay careful attention to information provided by the manufacturer of any drugs or equipment that they plan to use.
List of contributors
|
vii |
Foreword by Alan H. DeCherney
|
xi |
1 Anatomy and embryology of the male reproductive tract and gonadal development
Jane M. Lewis & William E. Kaplan
|
1 |
2 Male hypothalamic–pituitary–gonadal axis
Ettore Caroppo
|
14 |
3 Leydig cell development and function
Barry R. Zirkin, Vassilios Papadopoulos, & Matthew P. Hardy
|
29 |
4 The Sertoli cell: morphology, function, and regulation
Joseph P. Alukal & Dolores J. Lamb
|
48 |
5 Spermatogenesis in the adult
Joseph P. Alukal, Dolores J. Lamb, Craig S. Niederberger, & Antoine A. Makhlouf
|
74 |
6 The epididymis and accessory sex organs
Terry T. Turner
|
90 |
7 An overview of the molecular mechanisms involved in human fertilization
Mónica H. Vazquez-Levin & Clara I. Marín-Briggiler
|
104 |
8 New concepts in the genetics of male reproduction and infertility
Paul J. Turek
|
122 |
9 Erection, emission, and ejaculation: mechanisms of control
Alexander Müller & John P. Mulhall
|
132 |
10 Office evaluation of the subfertile male
Mark Sigman, Larry I. Lipshultz, & Stuart S. Howards
|
153 |
11 Evaluation of sperm function
Armand Zini & Mark Sigman
|
177 |
12 Endocrine evaluation
Rebecca Z. Sokol
|
199 |
13 Testicular biopsy in male infertility evaluation
Joseph P. Alukal, Mohit Khera, & Thomas M. Wheeler
|
215 |
14 Adverse effects of environmental chemicals and drugs on the male reproductive system
James V. Bruckner, David M. Fenig, & Larry I. Lipshultz
|
226 |
15 Genetic aspects of infertility
Robert D. Oates & Dolores J. Lamb
|
251 |
16 Immunologic infertility
Thomas J. Walsh & Paul J. Turek
|
277 |
17 The effect of genital tract infection and inflammation on male infertility
Sanjay S. Kasturi, E. Charles Osterberg, Justin Tannir, & Robert E. Brannigan
|
295 |
18 Varicocele
Harris M. Nagler & Aaron B. Grotas
|
331 |
19 Evaluation of female infertility for the non-gynecologist
R. Dale McClure & Nancy A. Klein
|
362 |
20 The use of ultrasound and radiologic imaging in the diagnosis of male infertility
Saleh Binsaleh, Myles Margolis, Keith Jarvi, & Kirk C. Lo
|
375 |
21 Microsurgical treatment of male infertility
Edmund S. Sabanegh Jr. & Anthony J. Thomas Jr.
|
392 |
22 Techniques of sperm retrieval
Edward Karpman & Daniel H. Williams IV
|
407 |
23 Management of ejaculatory duct obstruction
Aleksander Chudnovsky & Victor M. Brugh III
|
421 |
24 Nonsurgical treatment of male infertility: specific therapy
Jesse N. Mills & Randall B. Meacham
|
430 |
25 Nonsurgical treatment of male infertility: empiric therapy
Karen E. Boyle
|
438 |
26 Abnormalities of ejaculation
Nancy L. Brackett, Dana A. Ohl, Jens Sønksen, & Charles M. Lynne
|
454 |
27 Male contraception and vasectomy
Stanton C. Honig & Jay I. Sandlow
|
474 |
28 Intrauterine insemination from the urologist’s perspective
Christine Mullin, James Stelling, & Richard A. Schoor
|
493 |
29 In-vitro fertilization and micromanipulation for male infertility
Rodrigo L. Pagani, Paulo C. Serafini, & Miguel Srougi
|
500 |
30 Psychological issues of infertility and assisted reproductive technology
Linda D. Applegarth
|
516 |
31 Legal issues in fertility preservation in the male
Susan L. Crockin & Elizabeth M. Bloom
|
528 |
32 Analyzing male fertility data
Antoine A. Makhlouf & Craig S. Niederberger
|
541 |
33 Semen analysis
Susan A. Rothmann & Angela A. Reese
|
550 |
34 Strict criteria for sperm morphology
Grace M. Centola & Rajasingam S. Jeyendran
|
574 |
35 Sperm processing techniques
Grace M. Centola & Rajasingam S. Jeyendran
|
582 |
36 Sperm banking: indications and techniques
Moshe Wald & Gail S. Prins
|
593 |
37 Tests for antisperm antibodies
Suresh C. Sikka & Wayne J. G. Hellstrom
|
603 |
38 Semen white blood cell assay
Joseph A. Politch & Deborah J. Anderson
|
613 |
39 Determination of seminal oxidants (reactive oxygen species)
Ashok Agarwal & Fnu Deepinder
|
618 |
40 Measurement of DNA fragmentation in human spermatozoa
Denny Sakkas
|
633 |
41 A look towards the future: advances in andrology expected to revolutionize the diagnosis and treatment of the infertile male
Dolores J. Lamb
|
642 |
Index
|
654 |
Ashok Agarwal PhD HCLD
Joseph P Alukal MD
Deborah J Anderson PhD
Linda D Applegarth EdD
Saleh Binsaleh MD FRCSC
Elizabeth M Bloom JD
Karen E Boyle MD
Nancy L Brackett PhD HCLD
Robert E Brannigan MD
James V Bruckner PhD
Victor M Brugh III MD
Ettore Caroppo MD
Grace M Centola PhD
Aleksander Chudnovsky MD
Susan L Crockin JD
Fnu Deepinder MD
David M. Fenig
Aaron B Grotas MD
Matthew P. Hardy (deceased)
Wayne J. G. Hellstrom MD
Stanton C Honig MD
Stuart S Howards MD
Keith Jarvi MD FRCSC
Rajasingam S Jeyendran PhD
William E Kaplan MD
Edward Karpman MD
Sanjay S Kasturi MD
Mohit Khera MD MBA MPH
Nancy A Klein MD
Dolores J Lamb PhD HCLD
Jane M Lewis MD
Larry I Lipshultz MD
Kirk C Lo MD CM FRCSC
Charles M Lynne MD
R. Dale McClure MD FACS FRCSC
Antoine A Makhlouf MD PhD
Myles Margolis MD FRCPC
Clara I. Marín-Briggiler PhD
Randall B Meacham MD
Jesse N Mills MD
John P Mulhall MD
Alexander Müller MD
Christine Mullin MD
Harris M Nagler MD FACS
Craig S Niederberger MD FACS
Robert D Oates MD
Dana A Ohl MD
E. Charles Osterberg BS
Rodrigo L Pagani MD
Vassilios Papadopoulos DPharm PhD
Joseph A Politch PhD
Gail S Prins PhD
Angela A Reese BS
Susan A Rothmann PhD HCLD
Edmund S Sabanegh Jr. MD
Denny Sakkas PhD
Jay I Sandlow MD
Richard A Schoor MD FACS
Paulo C Serafini MD
Mark Sigman MD
Suresh C Sikka PhD HCLD
Rebecca Z Sokol MD MPH
Jens Sønksen MD DMSci PhD
Miguel Srougi MD
James Stelling MD
Justin Tannir MD
Anthony J Thomas Jr. MD
Paul J Turek MD
Terry T Turner PhD
Mónica H. Vazquez-Levin PhD
Moshe Wald MD
Thomas J Walsh MD MS
Thomas M Wheeler MD
Daniel H Williams IV MD
Armand Zini MD
Barry R Zirkin PhD