SILVA’S DIAGNOSTIC RENAL PATHOLOGY

THE KIDNEYS perform many vital functions, but their primary role as a filter of plasma, receiving approximately 25% of the cardiac output, makes them extremely susceptible to disease. These diseases often can only be diagnosed by renal biopsy, a complicated diagnostic procedure requiring that the pathologist integrate the findings of light microscopy, immunofluorescence, and electron microscopy. Because of the expertise required to practice renal pathology, many academic centers maintain a separately designated, specialized renal pathology laboratory for interpretation of medical renal diseases. This book covers all approaches and technical methods used by renal pathologists to diagnose a wide range of kidney diseases. Unlike most textbooks in the field, this book’s level of coverage is situated midway between encyclopedic and superficial, with the needs of the practicing (“signing-out”) pathologist in mind. While focusing on medical diseases of the kidney, the book also covers a full spectrum of renal tumors (both pediatric and adult). Its numerous diagnostic algorithms provide a simplified road map that directs the reader to the major patterns of interest. The text is illustrated with more than 1,000 photomicrographs and diagrams. The accompanying CD-ROM includes a supplemental set of images.

Xin J. Zhou, MD, is Drs. George & Anne Race Distinguished Professor of Pathology, director of renal pathology, and professor of internal medicine at the University of Texas Southwestern Medical Center, Dallas. Dr. Zhou has published extensively in the areas of renal diseases and has served on the editorial boards of several prestigious renal journals. Dr. Zhou is past president of the Chinese American Society of Nephrology.

Zoltan Laszik, MD, is associate professor of clinical pathology at the University of California at San Francisco School of Medicine. Dr. Laszik, a renowned renal pathologist, has published nearly 100 original papers and book chapters.

Tibor Nadasdy, MD, is professor of pathology and director of renal pathology at Ohio State University School of Medicine, Columbus. Dr. Nadasdy, an experienced academic renal pathologist, has published numerous original papers and book chapters in the fields of renal pathology and renal transplantation.

Vivette D. D’Agati, MD, is professor of pathology and director of renal pathology at Columbia University, College of Physicians and Surgeons, in New York. Dr. D’Agati has published more than 300 original articles and book chapters and coedited several renal pathology texts. She serves on the editorial boards of the major nephrology journals and has directed the Columbia University Renal Biopsy Course for more than two decades. She is past president of the Renal Pathology Society.

Fred G. Silva, MD, is executive vice-president/secretary-treasurer of the United States and Canadian Academy of Pathology, Augusta, Georgia. Dr. Silva is adjunct professor of pathology at Emory University and the Medical College of Georgia. He is formerly the Lloyd Rader Professor and chair of the department of pathology at the University of Oklahoma Health Sciences Center. Dr. Silva, a preeminent expert in renal pathology, has published hundreds of articles on subjects spanning the entire spectrum of renal pathology and coedited several renal pathology books.

Xin J. Zhou

University of Texas Southwestern Medical Center

Zoltan Laszik

University of California at San Francisco School of Medicine

Tibor Nadasdy

Ohio State University Medical Center

Vivette D. D’Agati

Columbia University, College of Physicians and Surgeons

Fred G. Silva

United States and Canadian Academy of Pathology

CAMBRIDGE UNIVERSITY PRESS
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Information on this title: www.cambridge.org/9780521877022
© Xin J. Zhou, Zoltan Laszik, Tibor Nadasdy, Vivette D. D’Agati, and Fred G. Silva 2009

This publication is in copyright. Subject to statutory exception and to the provisions of relevant collective licensing agreements, no reproduction of any part may take place without the written permission of Cambridge University Press.

First published 2009

Printed in the United States of America

A catalog record for this publication is available from the British Library.

Library of Congress Cataloging in Publication DataSilva’s diagnostic renal pathology / edited by Xin J. Zhou … [et al.].p. ; cm.Includes bibliographical references and index.ISBN 978-0-521-87702-2 (hardback)1. Kidneys – Pathophysiology. 2. Kidneys – Diseases – Diagnosis. 3. Kidneys – Biopsy. 4. Kidneys – Diseases – Atlases. I. Zhou, Xin J., 1962– II. Silva, Fred G. III. Title: Diagnostic renal pathology.[DNLM: 1. Biopsy – methods. 2. Kidney Diseases – pathology. 3. Kidney Diseases – classification. 4. Kidney Diseases – physiopathology. WJ 302 S5862009]RC903.9.S55 2009616.6′1075 – dc22 2008047233

ISBN 978-0-521-87702-2 hardback

Every effort has been made in preparing this publication to provide accurate and up-to-date information that is in accord with accepted standards and practice at the time of publication. Nevertheless, the authors, editors, and publisher can make no warranties that the information contained herein is totally free from error, not least because clinical standards are constantly changing through research and regulation. The authors, editors, and publisher therefore disclaim all liability for direct or consequential damages resulting from the use of material contained in this publication. Readers are strongly advised to pay careful attention to information provided by the manufacturer of any drugs or equipment that they plan to use.Cambridge University Press has no responsibility for the persistence or accuracy of URLs for external or third-party Internet Web sites referred to in this publication and does not guarantee that any content on such Web sites is, or will remain, accurate or appropriate. Information regarding prices, travel timetables, and other factual information given in this work are correct at the time of first printing, but Cambridge University Press does not guarantee the accuracy of such information thereafter.

ZHOU

To my loving wife, Jian Wang, and our wonderful children, Jason and Jaclyn

LASZIK

To my beautiful wife, Erika, and our wonderful children, Nandi, Laura, and Aron

NADASDY

To my wife, Gyongyi, and my daughters, Krisztina and Orsolya

D’AGATI

To my devoted husband, Edward Imperatore, and my loving children, Edward and Paul, without whose constant support and encouragement my academic career would not be possible

SILVA

To my lovely wife, Jean, and wonderful daughter, Lindsay

Contents

Contributors

MAHUL B. AMIN, MD

PEDRAM ARGANI, MD

STEVEN A. BIGLER, MD

WILLIAM L. CLAPP, MD

VIVETTE D. D′AGATI, MD

LUKAS HARAGSIM, MD

RANDOLPH A. HENNIGAR, MD, PhD

GUILLERMO A. HERRERA, MD

MICHAEL D. HUGHSON, MD

ZOLTAN G. LASZIK, MD, PHD

GLEN S. MARKOWITZ, MD

SHANE M. MEEHAN, MD

GYONGYI NADASDY, MD

TIBOR NADASDY, MD, PHD

SAMIH H. NASR, MD

DINESH RAKHEJA, MD

THOMAS E. ROGERS, MD

ANJALI SATOSKAR, MD

FRED G. SILVA, MD

MICHAEL B. STOKES, MD

SATISH K. TICKOO, MD

ROBERT D. TOTO, MD

JAMES A. TUMLIN, MD

ARTHUR G. WEINBERG, MD

XIN J. ZHOU, MD